abstract：:This study aimed to synthesize and characterize L-epigallocatechin gallate (EGCG) complexed Mn2+ nanoparticle (L-EGCG-Mn), a proof-of-concept pH-sensitive manganese core nanoparticle (NP), and compare its magnetic resonance (MR) properties with those of Gd-DTPA, both in vitro and in vivo. Reverse microemulsion was use...

authors： Li J,Jiang X,Shang L,Li Z,Yang C,Luo Y,Hu D,Shen Y,Zhang Z

更新日期：2021-12-01 00:00:00

abstract：:Acne Vulgaris is one of the most common chronic inflammatory skin disorders that affect majority of teen-agers worldwide. Isotretinoin (ITT) is the drug of choice in the management of acne, but, it suffers from serious side-effects including hepatotoxicity, and some psychological disturbances following its oral intake...

authors： Hosny KM,Alhakamy NA,Al Nahyah KS

更新日期：2021-12-01 00:00:00

abstract：:New piperazine-chalcone hybrids and related pyrazoline derivatives have been designed and synthesised as potential vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitors. The National Cancer Institute (NCI) has selected six compounds to evaluate their antiproliferative activity in vitro against 60 human ca...

authors： Ahmed MF,Santali EY,El-Haggar R

更新日期：2021-12-01 00:00:00

abstract：:The purpose of this study was to examine the role of using a gym as a mechanism for adherence to regular physical exercise among individuals with aged 55 and over. This was a grounded theory research design. Data were collected from face-to-face interviews and observations among 15 people who attended the gym regularl...

authors： Chen MH,Yu CL,Chang SH

更新日期：2021-12-01 00:00:00

abstract：:Purpose: The number of people aged 80 and above is projected to triple over the next 30 years. Expanding public expenditure on long-term care servicesHas made policies encouraged informal caregiving. Burden of care describes challenges connected to informal caregiving. Dependent patients report feelings of being a bur...

authors： Lilleheie I,Debesay J,Bye A,Bergland A

更新日期：2021-12-01 00:00:00

abstract：:Magnetic drug targeting (MDT) is an application in the field of targeted drug delivery in which magnetic (nano)particles act as drug carriers. The particles can be steered toward specific regions in the human body by adapting the currents of external (electro)magnets. Accurate models of particle movement and control a...

authors： Van Durme R,Crevecoeur G,Dupré L,Coene A

更新日期：2021-12-01 00:00:00

abstract：:Pleurostoma species are wood-inhabiting fungi and emerging opportunistic pathogens causing phaeohyphomycosis. In this study, we isolated a dematiaceous fungus, HKU44T, from the subhepatic abscess pus and drain fluids of a liver transplant recipient with post-transplant biliary and hepatico-jejunostomy bypass stricture...

authors： Tsang CC,Chan KF,Chan W,Chan JFW,Au-Yeung RKH,Ngan AHY,Lin KPK,Lau SKP,Woo PCY

更新日期：2021-12-01 00:00:00

abstract：:In recent years, nanocrystal technology has been extensively investigated. Due to the submicron particle size and unique physicochemical properties of nanocrystals, they overcome the problems of low drug solubility and poor bioavailability. Although the structures of nanocrystals are simple, the further development of...

authors： Li J,Wang Z,Zhang H,Gao J,Zheng A

更新日期：2021-12-01 00:00:00

abstract：:Purpose: Choice and autonomy are recognized as values facilitating genuine self-determination. Subsequently greater understanding of these concepts in decision-making practices of adults with intellectual disabilities is required. Aims: The twofold aim of this research study was to ascertain the core concern (most imp...

authors： Carey E

更新日期：2021-12-01 00:00:00

abstract：:Purpose: To describe experiences of living with balance limitations after first-ever stroke. Materials and methods: This study has a qualitative design, comprising interviews with 19 persons with first-ever stroke, ten women and nine men. Their mean age was 77 years and the mean time since stroke was 15 months. Stroke...

authors： Arvidsson Lindvall M,Forsberg A,Appelros P,Anderzén-Carlsson A

更新日期：2021-12-01 00:00:00

abstract：:A series of Plectranthus spp. plant extracts (aqueous, acetonic, methanolic and ethyl acetic) obtained from eight different species, and previously isolated compounds (ranging from polyphenols, diterpenes and triterpenes), were assayed for in vitro inhibition of the skin-related enzymes tyrosinase, collagenase and ela...

authors： Andrade JM,Domínguez-Martín EM,Nicolai M,Faustino C,Rodrigues LM,Rijo P

更新日期：2021-12-01 00:00:00

abstract：:COVID-19 is a respiratory illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and declared by the World Health Organization a global public health emergency. Among the severe outbreaks across South America, Uruguay has become known for curtailing SARS-CoV-2 exceptionally well. To understand ...

authors： Elizondo V,Harkins GW,Mabvakure B,Smidt S,Zappile P,Marier C,Maurano MT,Perez V,Mazza N,Beloso C,Ifran S,Fernandez M,Santini A,Perez V,Estevez V,Nin M,Manrique G,Perez L,Ross F,Boschi S,Zubillaga MN,Balleste R,

更新日期：2021-12-01 00:00:00

abstract：:Globally, hepatocellular carcinoma (HCC) is one of the most common causes of cancer-associated mortalities. It has a high rate of metastasis and recurrence, which predict a poor prognosis. G-protein-coupled receptor (GPCR)-kinase interacting protein-1 (GIT1) is a multifunctional scaffold protein that mediates the prog...

authors： Wang G,Bai X,Jiang G,Jin S,Wang Q,Wang A,Peng R,Ke A,Bai D

更新日期：2021-12-01 00:00:00

abstract：:A series of 3-subsituted quinolinehydroxamic acids has been synthesised and evaluated for their effect on human lung cancer cell line (A549), human colorectal cancer cell line (HCT116) and HDAC isoforms 1, 2, 6, and 8. The results indicated that substitution at C3 of quinoline is favoured for HDAC6 selectivity. Two co...

authors： Mehndiratta S,Chen MC,Chao YH,Lee CH,Liou JP,Lai MJ,Lee HY

更新日期：2021-12-01 00:00:00

abstract：:Fragment-based lead discovery (FBLD) is one of the most efficient methods to develop new drugs. We present here a new computational protocol called High-Throughput Supervised Molecular Dynamics (HT-SuMD), which makes it possible to automatically screen up to thousands of fragments, representing therefore a new valuabl...

authors： Ferrari F,Bissaro M,Fabbian S,De Almeida Roger J,Mammi S,Moro S,Bellanda M,Sturlese M

更新日期：2021-12-01 00:00:00

abstract：Background:Due to a pattern known as Marginalization-related Diminished Returns (MDRs), historically oppressed non-Hispanic Black Americans show weaker effects of economic status on health and development, when compared to socially privileged non-Hispanic White Americans. Such MDRs are also documented for the effects o...

authors： Assari S,Boyce S

更新日期：2021-11-29 00:00:00

abstract：...

authors： Park D,Kim JW,Shin K,Kim JW

更新日期：2021-11-15 00:00:00

abstract：:Pseudobulb of Cremastra appendiculata (Orchidaceae) is a traditionally used medicine in China for treatment of certain cancers. The polysaccharides from this medicinal plant are poorly understood. Therefore, we focused on the isolation and fine structure characterization of C. appendiculata polysaccharides. After isol...

authors： Zhang X,Bi C,Shi H,Li X

更新日期：2021-11-15 00:00:00

abstract：:In this study, Borassus flabellifer (Linn.) (BF) immature endosperm was decellularized to produce three dimensional (3D) cellulose scaffolds that can support mammalian 3D cell culture. To this regard, we first evaluated the chemical composition, nutritive profile and pharmacological activities of BF endosperm. The res...

authors： Mahendiran B,Muthusamy S,Selvakumar R,Rajeswaran N,Sampath S,Jaisankar SN,Krishnakumar GS

更新日期：2021-11-15 00:00:00

abstract：:Sea cucumber sulfated fucan (SC-FUC) attracted increasing interests in the recent decades. Endo-1,3-fucanase has been employed in the structural clarification and structure-function relationship investigations of SC-FUC. Nevertheless, the preparation of wild-type endo-1,3-fucanase is costly and time-consuming, which h...

authors： Chen G,Yu L,Zhang Y,Chang Y,Liu Y,Shen J,Xue C

更新日期：2021-11-15 00:00:00

abstract：:Plastic pollution has steadily become a global issue due to its ubiquity and degradation into micro and nanoparticles. Herein, we report the construction of surface-enhanced Raman scattering (SERS)-active array substrates with regenerated cellulose (RC) and plasmonic nanoparticles (AuNRs and AgNWs) via a simple vacuum...

authors： Jeon Y,Kim D,Kwon G,Lee K,Oh CS,Kim UJ,You J

更新日期：2021-11-15 00:00:00

abstract：:This research study highlights the catalytic usage of hetero atoms doped and undoped biogenic carbon nano dots (BCNDs) in the reduction of Alizarine yellow R (AYR) dye. Hydrothermal route was followed to synthesize the eco-friendly and fluorescent undoped as well as, N, B & S doped BCNDs from Syzygium cumini (S. cumin...

authors： Dhanush C,Sethuraman MG

更新日期：2021-11-05 00:00:00

abstract：:We have used bioinformatics to identify drugs for the treatment of COVID-19, using drugs already being tested for the treatment as benchmarks like Remdesivir and Chloroquine. Our findings provide further support for drugs that are already being explored as therapeutic agents for the treatment of COVID-19 and identify ...

authors： Ouled Aitouna A,Belghiti ME,Eşme A,Anouar E,Ouled Aitouna A,Zeroual A,Salah M,Chekroun A,Alaoui El Abdallaoui HE,Benharref A,Mazoir N

更新日期：2021-11-05 00:00:00

abstract：...

authors： Zhang Y,Tang Y,Zhang Y,Sun Y,Yang H

更新日期：2021-11-01 00:00:00

abstract：...

authors： Wade AT,Guenther BA,Ahmed FS,Elias MF

更新日期：2021-11-01 00:00:00

abstract：...

authors： Guarino F,Improta G,Triassi M,Castiglione S,Cicatelli A

更新日期：2021-11-01 00:00:00

abstract：...

authors： Hung KC,Huang ZY,Yow JL,Hsu TC,Tzang BS

更新日期：2021-11-01 00:00:00

abstract：...

authors： Kim S,Alais D

更新日期：2021-11-01 00:00:00

abstract：...

authors： Zhang J,He W,Zheng D,He Q,Tan M,Jin J

更新日期：2021-11-01 00:00:00

abstract：...

authors： Pu H,Qian Q,Wang F,Gong M,Ge X

更新日期：2021-11-01 00:00:00

abstract：...

authors： La Colla NS,Botté SE,Simonetti P,Negrin VL,Serra AV,Marcovecchio JE

更新日期：2021-11-01 00:00:00

abstract：...

authors： Li M,Zheng Z

更新日期：2021-11-01 00:00:00

abstract：...

authors： Rajkumar RP

更新日期：2021-11-01 00:00:00

abstract：...

authors： Chen M,Wang C,Gao K,Wang X,Fu J,Gong P,Wang Y

更新日期：2021-11-01 00:00:00

abstract：...

authors： Guo F,Tian J,Cui M,Fang M,Yang L

更新日期：2021-11-01 00:00:00

abstract：:Airway epithelial cells, which are the first physical defense barrier against allergens, play a pivotal role in immunity, airway inflammation and airway remodeling. The damage and dysfunction of these cells trigger the development of airway inflammatory diseases. Exosomes, which exist in various bodily fluids, mediate...

authors： Liu C,Huang XL,Liang JP,Zhong X,Wei ZF,Dai LX,Wang J

更新日期：2021-11-01 00:00:00

abstract：:Autohydrolysis is used for producing xylan-derived oligosaccharides from lignocellulosic biomass. Although numerous studies report optimized autohydrolysis conditions for various plants, few of these studies correlate process parameters with the resulting structural properties to their impact on intestinal bacterial c...

authors： Zhao S,Dien BS,Lindemann SR,Chen MH

更新日期：2021-11-01 00:00:00

abstract：:Ascorbic acid (AA) and glutathione (GSH), the most abundant intracellular reductive substances, have been widely used as biomarkers for cancer cells identification. The current methods relying on imaging of AA or GSH alone to identify cancer cells may cause systematic errors, since a mutual conversion relationship exi...

authors： Li C,Xu Y,Liu SY,Zhang Y,Yin W,Dai Z,Zou X

更新日期：2021-11-01 00:00:00

abstract：...

authors： Gopinath N

更新日期：2021-11-01 00:00:00

abstract：:Separating Yersinia pseudotuberculosis and Yersinia pestis is an important issue in plague diagnosis but can be extremely difficult because of the high similarity between the two species. MALDI-TOF MS has grown as a diagnostic tool with great potential in bacterial identification. Its application in this field is larg...

authors： Feng B,Shi L,Zhang H,Shi H,Ding C,Wang P,Yu S

更新日期：2021-11-01 00:00:00